
Therapeutic effect: Folic Acid with B6 and B12
High plasma homocysteine is linked to the risk of diabetes-related cardiovascular disease, nephropathy, and proliferative retinopathy. Co-supplementing with pyridoxine (vitamin B6), folic acid (vitamin B9), and vitamin B12 helps reduce homocysteine levels and the risk of cardiovascular disease. In the HOPE-2 study with 5,522 patients, high-dose B6, B9, and B12 cosupplementation decreased the risk of stroke. For patients on hemodialysis, folate and methylcobalamin (a B12 vitamer) cosupplementation also reduced homocysteine and asymmetric di-methylarginine (ADMA) levels, the nitric oxide synthase inhibitor.
Folic acid's role in Manhood


Folic acid and B12 can boost memory
Recommentation for Folic Acid
Folic acid is most effective when taken with a quality multivitamin and mineral supplements. An intake of 1 mg is safe and beneficial over the long term. For those at risk of deficiency, 400-800 mcg supplementation is recommended. Folic acid’s water-soluble nature allows rapid removal from the body even after an overdose. The kidneys filter it out of the blood and excrete it in the urine, ending any side effects of an overdose.


Importance of Vitamin B6
Vitamin B6 is vital for the body, and its deficiency has numerous detrimental effects on health, commonly observed in individuals following a North-American diet. Recent national health data in the USA reveals that 90% of women and 71% of men do not meet the Recommended Dietary Allowance (RDA) for this vitamin.
Low intake of foods rich in highly bioavailable vitamin B6, alongside medication use, pollutant exposure, and chronic digestive disorders, contribute to poor B6 status.
Diabetics and women over sixty-five are at higher risk of B6 deficiency. This deficiency leads to microcytic hypochromic anemia, glossitis, dermatitis, depression, and increase the risk of heart diseases.